Research Papers In Biochemistry

Top 7 biochemistry papers

#1 Complex I enzyme revealed The solved structure of a bacterial complex I enzyme -- first in line in the energy-producing respiratory chain -- reveals important mechanics of this ubiquitous protein. Specifically, the structure shows how it hustles electrons and protons across membranes. R.G. Efremov et al. "The architecture of respiratory complex I,"

#1 Complex I enzyme revealed The solved structure of a bacterial complex I enzyme -- first in line in the energy-producing respiratory chain -- reveals important mechanics of this ubiquitous protein. Specifically, the structure shows how it hustles electrons and protons across membranes. R.G. Efremov et al. "The architecture of respiratory complex I," Nature, 465(7297):441-5. 2010. linkurl:Eval; by Nathan Nelson, Tel Aviv University; Andrea Mattevi, University of Pavia; Terrence Frey, San Diego State University; Thomas Meier, Max Planck Institute of Biophysics.
#2 Unusual aging in E. coli A novel microfluidics technique allowed researchers to study single E. coli cells as they birthed many clones throughout many generations -- proving their growth rate wasn't hampered by age, contradicting previous hypotheses and other aging models. P. Wang et al. "Robust Growth of Escherichia coli," Curr Biol, 20: 1099-1103. 2010. linkurl:Eval; by Roy Kishony, Harvard University; Thomas Meier, Max Planck Institute of Biophysics.#3 Why proteins have knots Proteins with knots in their structures do not come untied when denatured, suggesting knots may play an unknown role in the ever-mysterious protein-folding process. A.L. Mallam et al. "Experimental detection of knotted conformations in denatured proteins," Natl Acad Sci, 107(18):8189-94. 2010. linkurl:Eval; by Werner Streicher and George Makhatadze, Rensselaer Polytechnic Institute; Aaron Burton and Niles Lehman, Portland State University.#4 Engineered: self-assembling membranes This synthesis of a broad class of organic molecules with both hydrophilic and hydrophobic properties that self-assemble into vesicles promises to be a huge leap toward efficient nanoscale delivery of drugs into cells. V. Percec et al. "Self-assembly of Janus dendrimers into uniform dendrimersomes and other complex architectures," Science, 328(5981):1009-14. 2010. linkurl:Eval; by Anthony Czarnik, University of Nevada; Donald Tomalia, Central Michigan University.#5 How proteins got their grooves back Crystal structures of one of the most abundant bacterial DNA-binding proteins show it will latch on to DNA depending on the size of its minor groove -- suggesting that DNA shape, and not just its base pair sequence, determines binding specificity. S. Stella et al. "The shape of the DNA minor groove directs binding by the DNA-bending protein Fis," Genes Dev, 24(8):814-26. 2010. linkurl:Eval; by Charles Dorman, Trinity College; Stephen CJ Parker and Tom Tullius; Boston University.#6 Predicting how proteins come together Researchers compiled a comprehensive benchmark against which algorithms that predict how proteins interact with one another can be tested, paving the way toward more accurate predictions. P.L. Kastritis and A.M. Bonvin. "Are scoring functions in protein-protein docking ready to predict interactomes? Clues from a novel binding affinity benchmark," J Proteome Res, 9(5):2216-25. 2010. linkurl:Eval; by Antonio Rosato, University of Florence; Gloria Fuentes and Chandra Verma, Bioinformatics Institute.#7 More clues to liver microRNA's role in disease By identifying small molecules that modulate the most abundant microRNA in the liver, researchers discovered it plays opposing roles in hepatitis C infection and liver cancer. D.D. Young et al. "Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma," J Am Chem Soc, 23: 7976-81. 2010. linkurl:Eval; by Subhash Sinha, The Scripps Research Institute; Nicholas Meanwell, Bristol Myers Squibb. The F1000 Top 7 is a snapshot of the highest ranked articles from a 30-day period on Faculty of 1000 Biochemistry, as calculated on June 30, 2010. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit
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24 Potential Topics For A Research Paper In Biochemistry

Most experienced students will tell you that it’s a lot easier to complete a particularly difficult assignment when one writes on an interesting and original topic. This is true across all disciplines, including biochemistry. Here are 24 potential topics for you to consider:

  1. Investigate the aggregation of B lymphocyte cell line from a chicken and determine its temperature sensitivity.
  2. What role does polyphosphate have on the virulence of what the Latin-named Erwinia caratovora?
  3. Using chemical shift information and data, attempt to predict protein dihedral angles.
  4. Discuss the dissection of cellular and molecular functions of the latest medications for the treatment of high blood pressure.
  5. Compare and contrast the major aspects of biochemical studies in the last half century compared to those likely in the next half century.
  6. Using rational protein engineering, analyze the expansion of substrate and template specificities in DNA strands.
  7. Analyze protein complexes defining DNA synthesis and assembly in patients with nephrotic syndrome.
  8. Analyze the molecular genetics of a single causative gene behind the muscular dystrophy.
  9. How does biochemical research help improve chances of developing sustainable food supply around the world?
  10. How does, what is often referred to as “good bacteria,” aid in maintaining gut health in humans?
  11. What supporting evidence is there for crops using GMO provide an answer the global food problems?
  12. How can mapping the human genome help prevent diseases and even help redesign human beings before life begins?
  13. Provide evidence for or against using animal models of disease for scientific value to aid in finding cures for human disease.
  14. Evaluate the close possibility of mapping the sequence of the entire human genome for a relative low cost.
  15. Write a research paper on the reasons why structural studies on complex biochemical compounds reveal valuable information towards DNA mapping.
  16. Describe the purification and expression of proteins’ reactions to interacting with ENTH at different levels.
  17. Provide a study of how athletes have used biomedical means to seek what many consider an unfair advantage over other athletes.
  18. What kind of impact would mapping the human genome have on society and medicine?
  19. Analyze recent advancements in biochemistry research that promises to lead to new medications.
  20. . How is studying and mapping genes important towards the development of new biochemical treatments for certain diseases?
  21. Study the society effects of the HPV vaccine in populations the have adopted the widespread use of the preventative measure.
  22. Review the reactions and basic structure of phosphates and esters as well as the synthesis required from alcohols.
  23. Discuss the process of photosynthesis on GMO crops and how does this affect the world’s population and hunger problems?
  24. Analyze the processes in with fatty-acid catabolism affects the human body.

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